- Bernard Marx, from George Bernard Shaw (or possibly Bernard of Clairvaux or possibly Claude Bernard) and Karl Marx.
- Lenina Crowne, from Vladimir Lenin, the Bolshevik leader during the Russian Revolution.
- Fanny Crowne, from Fanny Kaplan, famous for an unsuccessful attempt to assassinate Lenin. Ironically, in the novel, Lenina and Fanny are friends.
- Helmholtz Watson, from the German physician and physicist Hermann von Helmholtz and the American behaviorist John B. Watson.
- Mustapha Mond, from Mustapha Kemal Atatürk, founder of Turkey after World War I, who pulled his country into modernisation and official secularism; and Sir Alfred Mond, an industrialist and founder of the Imperial Chemical Industries conglomerate.
- Arch-Community Songster of Canterbury, a parody of the Archbishop of Canterbury and the Anglican Church's decision in August 1930 to approve limited use of contraception.
- Popé, from Popé, the Native American rebel who was blamed for the conflict now known as the Pueblo Revolt.
- John the Savage, after the term "noble savage" originally used in the verse drama The Conquest of Granada by John Dryden, and later erroneously associated with Rousseau.
-Albert Einstein
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